Estrogen Receptor/ERR Ligand

Estrogen Receptor/ERR Ligands (19):

Cat. No.	Product Name	Effect	Purity

HY-107245

Segetalin B	Ligand	99.56%
Segetalin B, an orally active cyclopentapeptide found in Vaccaria segetalis, possesses estrogen-like activity. Segetalin B promotes mineralization of ovariectomized rat-derived bone marrow mesenchymal stem cells (BMSCs) in vitro and increases the level of osteocalcin, BMP-2, ALP, and SIRT1 activity. Segetalin B is promising for research of post-menopausal osteoporosis (PMOP).

HY-W011926

Diisopropyl phthalate	Ligand	99.37%
Diisopropyl phthalate (DiPP) is a phthalate diester, which is widely used as an additive in plastics and consumer products. Diisopropyl phthalate has a weak binding ability to the recombinant human estrogen receptor, with an IC₅₀ of 41000 μM.

HY-W011926S

Diisopropyl phthalate-d₄	Ligand	98.8%
Diisopropyl phthalate-d₄ (DiPP-d₄) is the deuterium labeled Diisopropyl Phthalate (HY-W011926). Diisopropyl phthalate (DiPP) is a phthalate diester, which is widely used as an additive in plastics and consumer products. Diisopropyl phthalate has a weak binding ability to the recombinant human estrogen receptor, with an IC₅₀ of 41000 μM.

HY-163467

CHEMBL4224880	Ligand
CHEMBL4224880 is an estrogen receptor-α (ER-α) binder.

HY-170334

ER ligand-7	Ligand
ER ligand-7 is the ligand for estrogen receptor, and can be used for synthesis of PROTAC ER Degrader-15 (HY-170332) as ligand for target protein.

HY-N8075

Artonin U	Ligand
Artonin U is an artonin. Artonin U can be isolated from Artocarpus species. Artonin U binds to hERα, as measured by docking score and Prime MM-GBSA binding free energy evaluation. Artonin U can be used in breast cancer research.

HY-P11153

HGH fragment 176-191	Ligand
HGH fragment 176-191 is a fragment of Human Growth Hormone. HGH fragment 176-191 binds with high affinity to Ki-67, MiB protein, and the estrogen receptor. HGH fragment 176-191 enhances the toxicity of Doxorubicin (HY-15142A)-loaded Chitosan nanoparticles against breast cancer.

HY-170339

ER ligand-5	Ligand
ER ligand-5 is the ligand for estrogen receptor, that can be used as ligand for target protein for PROTAC synthesis of PROTAC ERα Degrader-10 (HY-170336).

HY-180851

ER ligand-14	Ligand
ER ligand-14 is an estrogen receptor (ER) ligand. ER ligand-14 can serve as a ligand for target protein for PROTAC, and can be used to develop and design degradative agents for PROTAC ERβ, such as ERB-2 (HY-180850). ERB-2 displays favorable antiproliferative activity against Osimertinib (HY-15772) resistance NSCLC cells.

HY-174475

ER ligand-11	Ligand
ER ligand-11 is the ligand for ERα and can be used for synthesis of PROTACs, such as PROTAC ERα Degrader-12 (HY-174453).

HY-180852

ER ligand-14-PEG3-Boc	Ligand
ER ligand-14-PEG3-Boc is a conjugate of a target protein ligand and linker, composed of an estrogen receptor ligand and a corresponding linker. ER ligand-14-PEG3-Boc can be used to synthesize PROTACs such as ERB-2 (HY-180850). ERB-2 exhibits good antiproliferative activity against Osimertinib (HY-15772)-resistant non-small cell lung cancer.

HY-184091

ER ligand-15	Ligand

HY-W749028

ERα ligand 4	Ligand
ERα ligand 4 is a ligand of ERα and can be used for the synthesis of PROTACs, such as NEP168 (HY-180959).

HY-B0141E

ent-Estradiol	Ligand
Ent-Estradiol is the enantiomer of Estradiol (HY-B0141). Ent-Estradiol is a highly selective estrogen receptor ligand, but does not possess estrogenic activity. Ent-Estradiol displays IC₅₀ values of 24.9 nM, 9.59 nM and 8.17 nM for human, rat and mouse ERβ, and 151 nM, 246 nM and 268 nM for human, rat and mouse ERα, respectively. Ent-Estradiol can be used for the study of menopausal physiological changes.

HY-180306

Fluoroestradiol	Ligand
Fluoroestradiol is an Estrogen receptor PET imaging tracer precursor. Fluoroestradiol, when radiolabeled with ¹⁸F, can be used as an Estrogen receptor PET imaging tracer. ¹⁸F-Fluoroestradiol exhibits the highest uptake selectivity and target-to-background ratio among several 18F-labeled estrogens. ¹⁸F-Fluoroestradiol has demonstrated Estrogen receptor expression in normal brain tissues and in meningiomas. ¹⁸F-Fluoroestradiol can quantify regional Estrogen receptor expression in breast cancer. ¹⁸F-Fluoroestradiol has potential applications in assessing and monitoring heterogeneity in ovarian cancer.

HY-W615671

4,4'-(Cyclohexylidenemethylene)diphenol	Ligand
4,4'-(Cyclohexylidenemethylene)diphenol (Compound 2) is a symmetric cyclic nonsteroidal estrogen. 4,4'-(Cyclohexylidenemethylene)diphenol has high binding affinity for estrogen receptors ERα and ERβ.

HY-49537

ER ligand-10	Ligand
ER ligand-10 (Compound 11a) is a weak ERa and ERβ ligand, and shows weak estrogenic activity.

HY-171477

Metahexestrol	Ligand
Metahexestrol is an estrogen receptor (E2R) inhibitor with antitumor activity. It significantly inhibits the proliferation of estrogen receptor-positive MCF-7 human breast cancer cells (ED₅₀ = 1.0 μM). Additionally, Metahexestrol also exhibits inhibitory effects in estrogen receptor-negative MDA-MB-231 cells, and its antiproliferative activity cannot be reversed by estrogen, suggesting that its mechanism of action may be partially independent of the E2R pathway. Metahexestrol can be used in research on estrogen-dependent breast cancer.

HY-W011926R

Diisopropyl phthalate (Standard)	Ligand
Diisopropyl phthalate (Standard) (DiPP (Standard)) is the analytical standard of Diisopropyl phthalate (HY-W011926). This product is intended for research and analytical applications. Diisopropyl phthalate (DiPP) is a phthalate diester, which is widely used as an additive in plastics and consumer products. Diisopropyl phthalate has a weak binding ability to the recombinant human estrogen receptor, with an IC₅₀ of 41000 μM.

Name
Email *

	Sorry, but the email address you supplied was invalid.